Publications 2016

  1. Poluzzi C, Iozzo RV, and Schaefer L. Endostatin and endorepellin: a common route of action for similar angiostatic cancer avengers. Adv Drug Deliv Rev 97: 156-173, 2016.

  2. Neill T, Schaefer L, and Iozzo RV. Decorin as a multivalent therapeutic agent against cancer. Adv Drug Deliv Rev 97: 174-185, 2016.

  3. Hsieh LT, Frey H, Nastase MV, Tredup C, Hoffmann A, Poluzzi C, Zeng-Brouwers J, Manon-Jensen T, Schröder K, Brandes RP, Iozzo RV, and Schaefer L. Bimodal role of NADPH Oxidases in the regulation of biglycan-triggered IL-1β synthesis. Matrix Biol 49: 61-81, 2016

  4. Berner A, Bachmann M, Bender C, Pfeilschifter J, Christen U and Mühl H. Though Active on RINm5F Insulinoma Cells and Cultured Pancreatic Islets, Recombinant IL-22 Fails to Modulate Cytotoxicity and Disease in a Protocol of Streptozotocin-Induced Experimental Diabetes. Front Pharmacol., 6: 317, 2016

  5. Ottenlinger F, Schwiebs A, Pfarr K, Wagner A, Grüner S, Mayer C, Pfeilschifter JM, Radeke HH. Fingolimod targeting protein phosphatase 2A differently affects IL-33 induced IL-2 and IFN-γ production in CD8(+) lymphocytes. Eur J Immunol., 46(4): 941-951, 2016.

  6. Shaabani N, Khairnar V, Duhan V, Zhou F, Tur RF, Häussinger D, Recher M, Tumanov AV, Hardt C, Pinschewer D, Christen U, Lang PA, Honke N, and Lang KS. Two separate mechanisms of enforced viral replication balance innate and adaptive immune activation. J Autoimmun., 67: 82-89, 2016.

  7. Bergis D, Kassis V, and Radeke HH. High plasma sST2 levels in gastric cancer and their association with metastatic disease. Cancer Biomarkers 16: 117–125, 2016

  8. Klionsky DJ, …. Schaefer, L,…. and Zughaier SM. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12: 1-222, 2016.

  9. Schaefer L and Reinhardt DP Extracellular matrix: Therapeutic tools and targets in cancer treatment. Adv Drug Deliv Rev 97: 1-3, 2016

  10. Grandoch M, Kohlmorgen C, Melchior-Becker A, Feldmann K, Homann S, Müller J, Kiene LS, Zeng-Brouwers J, Schmitz F, Nagy N, Polzin A, Gowert NS, Elvers M, Skroblin P, Yin X, Mayr M, Schaefer L, Tannock L, and Fischer JW. Loss of biglycan enhances thrombin generation in ApoE-deficient mice: Implications for inflammation and atherosclerosis. Arterioscler Thromb Vasc Biol 36: e41-50, 2016

  11. Mühl, H. STAT3, a key parameter of cytokine-driven tissue protection during sterile inflammation – the case of experimental acetaminophen (paracetamol)-induced liver damage. Front Immunol. 7: 163, 2016

  12. Nastase MV, Zeng-Brouwers J, Frey H, Hsieh LT, Poluzzi C, Beckmann J, Schroeder N, Pfeilschifter J, Lopez-Mosqueda J, Mersmann J, Ikeda F, Iozzo RV, Dikic I, and Schaefer L. An essential role for SHARPIN in the regulation of caspase 1 activity in sepsis. Am J Pathol 186: 1206-1220, 2016

  13. Schmidt F, Müller M, Prox J, Arnold P, Schönherr C, Tredup C, Minder P, Ebsen H, Janssen O, Annaert W, Pietrzik C, Schmidt-Arras D, Sterchi EE, and Becker-Pauly C. Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains. Biol Chem., 397(9): 857-869, 2016

  14. Coldewey SM, Benetti E, Collino M, Pfeilschifter J, Sponholz C, Bauer M, Huwiler A, and Thiemermann C. Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis.Sci Rep. 6:27594, 2016

  15. Grammatikos G, Schoell N, Ferreirós N, Bon D, Herrmann E, Farnik H, Köberle V, Piiper A, Zeuzem S, Kronenberger B, Waidmann O, and Pfeilschifter J. Serum sphingolipidomic analyses reveal an upregulation of C16- ceramide and sphingosine-1-phosphate in hepatocellular carcinoma. Oncotarget, 7(14): 18095-18105, 2016

  16. Grammatikos G, Dietz J, Ferreiros N, Koch A, Dultz G, Bon D, Karakasiliotis I, Lutz T, Knecht G, Gute P, Herrmann E, Zeuzem S, Mavromara, Sarrazin C, and Pfeilschifter J. Persistence of HCV in acutely-infected patients depletes C24-ceramide and upregulates sphingosine and sphinganine serum levels. Int J Mol Sci, 17: 922, 2016

  17. Barallobre-Barreiro J, Gupta S, Zoccaratto A, Fava M, Yin X, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah A, Jahangiri M, Schaefer L, Fischer J, Iozzo RV, Viner R, Kichler A, Thum T, Heineke J, and Mayr M. Glypoproteomix reveals decorin fragments with anti-myostatin activity in human atrial fibrillation. Circulation, 134: 817-832, 2016

  18. Imeri F, Schwalm S, Lyck R, Zivkovic A, Stark H, Engelhardt B, Pfeilschifter J, and Huwiler A. Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments. Neuropharmacology, 105: 341-350, 2016

  19. Müller P, Messmer M, Bayer M, Pfeilschifter JM, Hintermann E, and Christen U. Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model. J Autoimmun., 69: 51-58, 2016

  20. Hintermann E, Bayer M, Ehser J, Aurrand-Lions M, Pfeilschifter JM, Imhof BA, and Christen U. Murine junctional adhesion molecules JAM-B and JAM-C mediate endothelial and stellate cell interactions during hepatic fibrosis. Cell Adh Migr., 10(4): 419-433, 2016

  21. Schwiebs A, Friesen O, Katzy E, Ferreirós N, Pfeilschifter JM, and Radeke HH. Activation-Induced Cell Death of Dendritic Cells Is Dependent on Sphingosine Kinase 1. Front Pharmacol., 7: 94, 2016

  22. Longen S, Richter F, Köhler Y, Wittig I, Beck KF, and Pfeilschifter J. Quantitative Persulfide Site Identification (qPerS-SID) Reveals Protein Targets of H2S Releasing Donors in Mammalian Cells. Sci Rep., 6: 29808, 2016

  23. Blankenbach KV, Schwalm S, Pfeilschifter J, and Meyer Zu Heringdorf D. Sphingosine-1-Phosphate Receptor-2 Antagonists: Therapeutic Potential and Potential Risks. Front Pharmacol., 7: 167, 2016

  24. Longen S, Beck KF, and Pfeilschifter J. H2S-induced thiol-based redox switches: Biochemistry and functional relevance for inflammatory diseases. Pharmacol Res., 111: 642-651, 2016

  25. Eberhardt W, Badawi A, Biyanee A, and Pfeilschifter J. Cytoskeleton-Dependent Transport as a Potential Target for Interfering with Post-transcriptional HuR mRNA Regulons. Front Pharmacol., 7: 251, 2016.

  26. Filipenko I, Schwalm S, Reali L, Pfeilschifter J, Fabbro D, Huwiler A, and Zangemeister-Wittke U. Upregulation of the S1P(3) receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE(2) and EP(2)/EP(4) activation. Biochim Biophys Acta., 1861(11): 1840-1851, 2016

  27. Ottenlinger F, Mayer CA, Ferreirós N, Schreiber Y, Schwiebs A, Schmidt A, Ackermann H, Pfeilschifter J, and Radeke HH. Interferon-beta increases plasma ceramides of specific chain length in multiple sclerosis patients, unlike fingolimod or natalizumab. Front Pharmacol., 7: 412, 2016

  28. Beetz N, Rommel C, Schnick T, Neumann E, Preissl S, Gilsbach R, Melchior-Becker A, Monroy-Ordonez E-B, Rylski B, Stoll M, Schaefer L, Beyersdorf F, Stiller B, and Hein L. Ablation of biglycan attenuates cardiac hypertrophy and fibrosis after left ventricular pressure overload. J Mol Cell Cardiol 101:145-155, 2016

  29. Wangorsch A, Larsson H, Messmer M, García-Moral A, Lauer I, Wolfheimer S, Schülke S, Bartra J, Vieths S, Lidholm J, Scheurer S. Molecular cloning of plane pollen allergen Pla a 3 and its utility as diagnostic marker for peach associated plane pollen allergy. Clin Exp Allergy, 46(5): 764-774, 2016

  30. Zakrzewicz D, Bergmann S, Didiasova M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Lochnit G, Schaefer L, Hammerschmidt S, Preissner KT, and Wygrecka M. Host-derived extracellular RNA promotes adhesion of Streptococcus pneumoniae to endothelial and epithelial cells. Sci Rep 6:37758

  31. Neill T, Buraschi S, Goyal A, Sharpe C, Natkanski E, Schaefer L, Morrione A, and Iozzo RV. EphA2 is a functional receptor for progranulin. J Cell Biol, 215: 687-703, 2016

  32. Christen U and Hintermann E. Immunopathogenic mechanisms of autoimmune hepatitis: How much do we know from animal models? Int J Mol Sci., 17(12), pii: E2007, 2016

  33. Zschiebsch K, Fischer C, Pickert G, Häussler A, Radeke H, Grösch S, Ferreirós N, Geisslinger G, Werner ER, and Tegeder I. Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling. J Crohns Colitis, 10(8): 965-78, 2016

  34. Siebert A, Goren I, Pfeilschifter J and Frank F. Anti-inflammatory effects of rosiglitazone in obesity-impaired wound healing depend on adipocyte differentiation. Plos One, 11(12): e0168562, 2016

  35. Heim K, Dälken B, Faust S, Rharbaoui F, Engling A, Wallmeier H, Dingermann T, Radeke HH, Schüttrumpf J, and Gutscher M.High thioredoxin-1 levels in rheumatoid arthritis patients diminish binding and signalling of the monoclonal antibody Tregalizumab.Clin Transl Immunology., 5(12): e121. doi: 10.1038/cti.2016.69. eCollection 2016, 2016

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